Preimplantation Genetic Diagnosis (PGD)
Preimplantation Genetic Diagnosis (PGD) is an advanced technique that detects specific genetic or chromosomal conditions in embryos before transfer. It’s especially helpful for couples at risk of passing on inherited disorders, allowing the selection of healthy embryos and increasing the chances of a successful, healthy pregnancy.
#UNDERSTANDING PGD
What is PGD?
Preimplantation genetic diagnosis (PGD) is a genetic screening procedure used in conjunction with assisted reproductive technology (ART), such as IVF, to help couples increase their chances of having a healthy pregnancy. This advanced technique involves testing embryos for chromosomal abnormalities that can lead to genetic disorders.
PGD provides couples with valuable insights about their embryos before implantation, helping them make informed reproductive choices. It is especially beneficial for those with a family history of genetic disorders, recurrent miscarriages, or advanced maternal age. By identifying potential risks early, PGD enhances confidence and improves outcomes in the IVF journey.
#THE ORIGINS OF PGD
History of PGD
PGD was first developed in 1989 by Alan Handyside as a means to detect cystic fibrosis in embryos created through IVF. It was also used for sex selection, as male embryos are at a higher risk of certain sex-linked diseases. Over time, PGD has evolved into a sophisticated genetic testing method that can identify single-gene disorders, chromosomal abnormalities, and sex-related conditions.
#How PGD Works
The PGD Process
Preimplantation Genetic Diagnosis (PGD) begins with creating embryos through IVF. A few cells are carefully tested for genetic disorders, and only healthy embryos are selected for transfer, helping ensure a higher chance of a successful pregnancy.
IVF: The couple undergoes IVF, retrieving eggs and fertilizing them in a lab.
Embryo Culture: Embryos are cultured for 3–5 days to blastocyst stage.
Biopsy: A few cells are extracted from the embryo for testing.
Genetic Analysis: Cells are tested for chromosomal abnormalities.
Embryo Transfer: Healthy embryos are transferred to the uterus.
#KEY BENEFITS
Benefits of PGS
PGS helps identify chromosomally normal embryos before transfer, improving implantation rates, reducing miscarriage risk, and preventing genetic disorders, ultimately increasing the chances of a healthy pregnancy.
Healthy Pregnancy
Select embryos without genetic disorders for higher success rates.
Reduced Risk
Avoid passing on serious genetic conditions to your children.
Peace of Mind
Reassurance that your child is free from genetic defects.
#Before You Proceed
Additional Considerations
While PGD offers significant benefits, it’s important to discuss potential risks, costs, and success rates with your fertility specialist. Understanding these factors can help you make informed decisions and ensure the best possible outcome for your family.
Cost
Treatment Expenses
PGD is a relatively expensive procedure.
Success Rate
Chances of Success
It increases chances but does not guarantee pregnancy.
Ethical Concerns
Moral Considerations
Some raise concerns about using PGD for sex selection or non-medical reasons.
#Talk to Our Experts
Book a Consultation with Our Doctors
If you are considering Preimplantation Genetic Diagnosis (PGD), we recommend consulting with Dr. Naila Jabeen for personalized guidance. She will provide a thorough discussion of the procedure, including its potential benefits and risks, and help you make informed decisions tailored to your specific needs and circumstances.